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Publication Detail
Cellular targets of regulatory B cell-mediated suppression.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Rosser EC, Blair PA, Mauri C
  • Publication date:
  • Pagination:
    296, 304
  • Journal:
    Mol Immunol
  • Volume:
  • Issue:
  • Status:
  • Country:
  • PII:
  • Language:
  • Keywords:
    Regulatory B cells, Tolerance, Animals, B-Lymphocytes, Regulatory, Humans, Immunosuppressive Agents, Inflammation, Interleukin-10, T-Lymphocytes, Regulatory
Regulatory B cells (Bregs) are defined by their ability to restrain inflammatory responses both in vivo and in vitro. Interleukin 10 (IL-10) production by Bregs is thought to be central to their ability to regulate inflammation, largely due to IL-10s' ability to suppress pro-inflammatory cytokine production by effector lymphocytes and to maintain the differentiation of regulatory T cells (Tregs). However, with an increase in available published data, it has become evident that Bregs utilize a number of suppressive mechanisms in order to alter the activation of a variety of different lymphocytes. Here, we summarize the multiplicity of cellular targets of Breg-mediated suppression and describe the mechanisms employed by Bregs to suppress chronic inflammatory responses.
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