Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Tailoring solubility and drug release from electrophoretic deposited chitosan-gelatin films on titanium
We prepared chitosan-gelatin (Chi-Gel) composite coatings on Ti via electrophoretic deposition (EPD) method for utilization in tissue repair and drug delivery. Uniform coatings were produced over a wide compositional range (0-75% Gel) with coating gains dependent on the EPD parameters including voltage and time. Coating degradation increased as the Gel content increased, with 16-54% weight losses after 3. weeks of immersion in phosphate buffered saline. Ampicillin, used as a model drug, was successfully incorporated within the coatings during the EPD process, and the release was highly sustainable with no burst effect up to a month, proving the potential of these materials as long-term drug eluting coatings. The release rate was dependent on the coating degradation, i.e., the more degradable with increasing Gel content, suggesting a rate-controllable drug release by a compositional change. Preliminary cell tests showed favorable cell adhesion and spreading on the composite coatings, with significant improvement in cell proliferation as Gel content increased. While more in-depth biological assays remain, the Chi-Gel might be useful as a drug eluting electrophoretic coating system on metallic implants for tissue repair. © 2013 Elsevier B.V.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Biomaterials & Tissue Eng
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by