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Publication Detail
Tailoring solubility and drug release from electrophoretic deposited chitosan-gelatin films on titanium
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Patel KD, Singh RK, Lee E-J, Han C-M, Won J-E, Knowles JC, Kim H-W
  • Publication date:
  • Pagination:
    232, 236
  • Journal:
    Surface and Coatings Technology
  • Volume:
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Chitosan, Composite coatings, Degradation, Drug eluting, Electrophoretic deposition, Gelatin
We prepared chitosan-gelatin (Chi-Gel) composite coatings on Ti via electrophoretic deposition (EPD) method for utilization in tissue repair and drug delivery. Uniform coatings were produced over a wide compositional range (0-75% Gel) with coating gains dependent on the EPD parameters including voltage and time. Coating degradation increased as the Gel content increased, with 16-54% weight losses after 3. weeks of immersion in phosphate buffered saline. Ampicillin, used as a model drug, was successfully incorporated within the coatings during the EPD process, and the release was highly sustainable with no burst effect up to a month, proving the potential of these materials as long-term drug eluting coatings. The release rate was dependent on the coating degradation, i.e., the more degradable with increasing Gel content, suggesting a rate-controllable drug release by a compositional change. Preliminary cell tests showed favorable cell adhesion and spreading on the composite coatings, with significant improvement in cell proliferation as Gel content increased. While more in-depth biological assays remain, the Chi-Gel might be useful as a drug eluting electrophoretic coating system on metallic implants for tissue repair. © 2013 Elsevier B.V.
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