Sickle cell disease (SCD) is an inherited blood disorder which may result in a broad range of complications including recurring and severe episodes of pain - sickle “crises” - which require frequent hospitalisations. We assessed the cost of hospitalisations associated with SCD with crisis in England. Methods Hospital Episodes Statistics data for all hospital episodes in England between 2010-2011, recording Sickle Cell Anaemia with Crisis as primary diagnosis were used. The total cost of admissions and exceeded length of stay due to SCD were assessed using the Healthcare Resource Groups ( HRGs) tariffs. The impact of patients’ characteristics on SCD admissions costs and the likelihood of incurring extra bed days were also examined. Results In 2010-2011, England had 6,077 admissions associated with SCD with crisis as primary diagnosis. The total cost for these admissions for commissioners was £18,798,255. The cost of admissions increases with age (children admissions costs 50% less than adults). Patients between 10-19 years old are more likely to stay longer in hospital compare to others. Conclusion SCD represents a significant cost for commissioners and the NHS. Further work is required to assess how best to manage patients in the community, which could potentially lead to a reduction in hospital admissions and length of stay, and their associated costs.