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Publication Detail
Single-molecule reconstruction of oligonucleotide secondary structure by atomic force microscopy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Pyne A, Thompson R, Leung C, Roy D, Hoogenboom BW
  • Publication date:
  • Pagination:
    3257, 3261
  • Journal:
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Language:
  • Keywords:
    DNA, atomic force microscopy, biomolecules, biophysics, oligonucleotides, DNA, Fourier Analysis, Microscopy, Atomic Force, Nucleic Acid Conformation
Based on soft-touch atomic force microscopy, a method is described to reconstruct the secondary structure of single extended biomolecules, without the need for crystallization. The method is tested by accurately reproducing the dimensions of the B-DNA crystal structure. Importantly, intramolecular variations in groove depth of the DNA double helix are resolved, which would be inaccessible for methods that rely on ensemble-averaging.
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