UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Oligodendrocyte progenitors: adult stem cells of the central nervous system?
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Crawford AH, Stockley JH, Tripathi RB, Richardson WD, Franklin RJM
  • Publication date:
    10/2014
  • Pagination:
    50, 55
  • Journal:
    Exp Neurol
  • Volume:
    260
  • Status:
    Published
  • Country:
    United States
  • PII:
    S0014-4886(14)00129-0
  • Language:
    eng
  • Keywords:
    Astrocyte, Multipotent, Neuron, Oligodendrocyte, Precursor cell, Progenitor cell, Regeneration, Remyelination, Schwann cell, Stem cell, Adult Stem Cells, Animals, Cell Differentiation, Central Nervous System, Humans, Oligodendroglia, Stem Cells
Abstract
Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name 'oligodendrocyte progenitor' suggests restriction to the oligodendrocyte cell lineage. However, with growing evidence of the lineage plasticity of OPs both in vitro and in vivo, we discuss whether they have potential beyond that expected of dedicated progenitor cells, and hence may justify categorization as adult stem cells.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Wolfson Inst for Biomedical Research
Author
Wolfson Inst for Biomedical Research
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by