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Publication Detail
14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Bertolaccini ML, Amengual O, Andreoli L, Atsumi T, Chighizola CB, Forastiero R, de Groot P, Lakos G, Lambert M, Meroni P, Ortel TL, Petri M, Rahman A, Roubey R, Sciascia S, Snyder M, Tebo AE, Tincani A, Willis R
  • Publication date:
    09/2014
  • Pagination:
    917, 930
  • Journal:
    Autoimmun Rev
  • Volume:
    13
  • Issue:
    9
  • Status:
    Published
  • Country:
    Netherlands
  • PII:
    S1568-9972(14)00120-7
  • Language:
    eng
  • Keywords:
    Antiprothrombin antibodies, Domain I, IgA, Lupus anticoagulant, Risk, aCL, Advisory Committees, Animals, Antibodies, Antiphospholipid, Antiphospholipid Syndrome, Autoantibodies, Congresses as Topic, Humans, beta 2-Glycoprotein I
Abstract
Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).
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