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Publication Detail
Regulatory B cells in experimental mouse models of arthritis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Rosser EC, Mauri C
  • Publication date:
    2014
  • Pagination:
    183, 194
  • Journal:
    Methods Mol Biol
  • Volume:
    1190
  • Status:
    Published
  • Country:
    United States
  • Language:
    eng
  • Keywords:
    Adoptive Transfer, Animals, Antigens, Arthritis, Experimental, B-Lymphocytes, Regulatory, Collagen, Disease Models, Animal, Female, Male, Mice
Abstract
Regulatory B cells (Bregs) have been shown to play a role in the suppression of a wide variety of immune responses. For the study of autoimmune inflammation, experimental models of arthritis have acted as a valuable tool in understanding the function of Bregs in maintaining immune homeostasis. In this chapter, we will focus on the study of transitional-2 marginal zone precursor Bregs (T2-MZPs) in the context of two experimental arthritis models: antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA). We will specifically focus on how to induce arthritis as well as methods for the isolation and functional study of Bregs both in vitro and in vivo.
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