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Publication Detail
Population genetics for target identification.
Abstract
In this review, we address how to best use data from the Human Genome Project to discover new drug targets for common disease. We focus on population genetic approaches to identify variants associated with disease and how these can illuminate new targets and pathways for intervention. We discuss new insights into patterns of human genetic variation, evolving strategies for genome-wide case-control design, and developments in bioinformatic technologies. Hypothesis versus non-hypothesis-driven approaches to target identification are considered.:
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Clinical and Movement Neurosciences
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