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Publication Detail
Attenuation correction synthesis for hybrid PET-MR scanners: application to brain studies.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Burgos N, Cardoso MJ, Thielemans K, Modat M, Pedemonte S, Dickson J, Barnes A, Ahmed R, Mahoney CJ, Schott JM, Duncan JS, Atkinson D, Arridge SR, Hutton BF, Ourselin S
  • Publication date:
    12/2014
  • Pagination:
    2332, 2341
  • Journal:
    IEEE Trans Med Imaging
  • Volume:
    33
  • Issue:
    12
  • Status:
    Published
  • Country:
    United States
  • Language:
    eng
  • Keywords:
    Algorithms, Brain, Humans, Magnetic Resonance Imaging, Multimodal Imaging, Neuroimaging, Positron-Emission Tomography
Abstract
Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.
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