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Publication Detail
Nonrigid registration improves MRI T2 quantification in heart transplant patient follow-up
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Odille F, Escanye J, Atkinson D, Bonnemains L, Felblinger J
  • Publication date:
  • Journal:
    Journal of Magnetic Resonance Imaging
  • Status:
  • Keywords:
    T2 mapping, cardiac transplantation, image registration
Purpose: To evaluate the use of a nonrigid registration technique for detecting acute heart transplant rejection by MRI T2 quantification. Material and Methods: Myocardial T2 quantification was achieved in 279 consecutive examinations from 78 different patients. The protocol consisted of ten successive black-blood fast spin echo sequences with varying echo times, and a post-processing based on image registration and exponential fitting. An automatic nonrigid registration method was applied to correct for myocardium misalignment. Finally T2 values were compared to those obtained with a conventional rigid registration followed by manual correction. Results: Nonrigid registration was feasible in 98% of the datasets and was judged of higher quality compared to conventional processing (p<0.001). No significant difference was found in the clinical outcome (average septal T2) between nonrigid and conventional registration (p=0.66). Inter-observer variability was improved with 95% limits of agreement of 2.7 ms (against 3.7 ms with conventional registration). The quality of T2 fitting, as assessed by the coefficient of determination R2, was significantly improved (p<0.001). Conclusion: Nonrigid registration improves T2 quantification in heart-transplant patient follow-up.
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