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Publication Detail
A novel method for implementation of frameless StereoEEG in epilepsy surgery.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Nowell M, Rodionov R, Diehl B, Wehner T, Zombori G, Kinghorn J, Ourselin S, Duncan J, Miserocchi A, McEvoy A
  • Publication date:
  • Pagination:
    525, 533
  • Journal:
  • Volume:
    10 Suppl 4
  • Status:
  • Country:
    United States
  • Language:
  • Keywords:
    Adolescent, Adult, Aged, Cohort Studies, Electrodes, Implanted, Electroencephalography, Epilepsy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multimodal Imaging, Neuronavigation, Prospective Studies, Tomography, X-Ray Computed, Treatment Outcome, Young Adult
BACKGROUND: Stereoelectroencephalography (SEEG) is an invasive diagnostic procedure in epilepsy surgery that is usually implemented with frame-based methods. OBJECTIVE: To describe a new technique of frameless SEEG and report a prospective case series at a single center. METHODS: Image integration and planning of electrode trajectories were performed preoperatively on specialized software and exported to a Medtronic S7 StealthStation. Trajectories were implemented by frameless stereotaxy using percutaneous drilling and bolt insertion. RESULTS: Twenty-two patients went this technique, with the insertion of 187 intracerebral electrodes. Of 187 electrodes, 175 accurately reached their neurophysiological target, as measured by postoperative computed tomography reconstruction and multimodal image integration with preoperative magnetic resonance imaging. Four electrodes failed to hit their target due to extradural deflection, and 3 were subsequently resited satisfactorily. Eight electrodes were off target by a mean of 3.6 mm (range, 0.9-6.8 mm) due to a combination of errors in bolt trajectory implementation and bending of the electrode. There was 1 postoperative hemorrhage that was clinically asymptomatic and no postoperative infections. Sixteen patients were offered definitive cortical resections, and 6 patients were excluded from resective surgery. CONCLUSION: Frameless SEEG is a novel and safe method for implementing SEEG and is easily translated into clinical practice.
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Clinical & Experimental Epilepsy
Clinical & Experimental Epilepsy
Institute of Neurology
Dept of Med Phys & Biomedical Eng
Clinical & Experimental Epilepsy
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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