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Publication Detail
Antenatal multiple micronutrient supplementation does not result in a difference in anthropometry and blood pressure in mid-childhood: follow-up of a double-blind randomized controlled trial in Nepal
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Devakumar D, Chaube SS, Wells J, Saville NM, Ayres JG, Manandhar DS, Costello A, Osrin D
  • Publisher:
  • Publication date:
  • Journal:
    The Lancet Global Health
  • Status:
  • Print ISSN:
  • Keywords:
    anthropometry, Nepal, child, micronutrients, prenatal exposure delayed effects
Background: In a randomized controlled trial in southern Nepal, we found that children born to mothers who had taken multiple micronutrient supplements during pregnancy had mean birthweight 77 g greater than a control group allocated to iron and folic acid supplements. They were a mean 204 g heavier at 2·5 years of age and their systolic blood pressure was a mean 2·5 mmHg lower. We followed the same children up in mid-childhood, hypothesizing that these differences would be sustained. Methods: We identified children from the original trial and measured anthropometry, body composition using bioelectrical impedance (with population-specific isotope calibration), blood pressure, and renal dimensions by ultrasound. We documented socieconomic status, household food security, and air pollution.Results: We assessed 841 children (422 control, 419 intervention) at mean age 8·5 years. Unadjusted differences (intervention minus control) were 0·05 z-scores (95% CI -0·09, 0·19) in weight-for-age, 0·02 z-scores (-0·10, 0·15) in height-for-age, and 0·04 z-scores (-0·09, 0·18) in body-mass-index-for-age. There was no difference in blood pressure. Adjusted differences were similar for all outcomes. Discussion: Differences in phenotype between children born to mothers who received antenatal multiple micronutrient or iron and folate supplements were not apparent at 8·5 years. Our findings did not extend to physiological differences or potential longer-term effects.
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