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Publication Detail
Mathematical models of colorectal tumour microstructure informed by oscillating gradients diffusion MRI
  • Publication Type:
  • Authors:
    Proverbio , Siow , Panagiotaki E, Walker-Samuel , Lythgoe , Gibson A, Alexander DC
  • Publication date:
  • Name of conference:
    Proceedings of the 23rd meeting of the International society for magnetic resonance in medicine 2014
Investigation of tissue microstructure with non-invasive histology is a developing research area. Diffusion MRI (dMRI) can estimate features of microstructural components such as cell cytoarchitecture. Here develop signal models for Square Wave Oscillating Gradient Spin Echo (SWOGSE) dMRI. This study is performed on fixed subcutaneous xenograft tumour samples grown in nude mice: 3 LS174T, and 3 SW1222 cell lines. Oscillating Gradient Spin Echo probes shorter length scales than standard PGSE. The more tissue-like compartment model appears to represent the signal better, suggesting the feasibility of a clinical measurement of cytological properties of the tissue.
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