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Publication Detail
Obesity: Causes, Consequences and Patient-Centred Therapeutic Approaches
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Pucci A, Batterham RL, Manning S
  • Publication date:
  • Pagination:
    21, 24
  • Journal:
  • Volume:
  • Issue:
Obesity is one of the greatest 21st century public health challenges. However, government strategies aimed at reducing the unprecedented levels of obesity have been largely unsuccessful to date (Institute of Medicine 2013). Only in 2013 the American Medical Association (AMA) identified the necessity for prevention and medical interventions in the obesity field, suggesting that clinicians are also lagging behind in the fight to halt the obesity epidemic (American Medical Association 2013). Excess weight is the fifth leading risk factor for global deaths. At least 2.8 million adults die each year as a result of being overweight or obese. In addition, approximately 44% of the type 2 diabetes (T2D) burden, 23% of the ischaemic heart disease burden and between 7% and 41% of certain cancer burdens are attributable to overweight and obesity. Obesity is also a major risk factor for numerous other health problems, including hypertension, respiratory and musculoskeletal problems. Mortality also increases above the overweight threshold in direct proportion to increasing body mass index (BMI) (Whitlock et al. 2009). In this article, we will briefly summarise the epidemiologic and economic burdens of obesity. We will also discuss the role of biological factors, with a focus on the gastrointestinal (GI) tract, the pathophysiology of obesity and how understanding the biology may hold the key to novel therapeutic approaches
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