Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Kavlie RG, Fritz JL, Nies F, Göpfert MC, Oliver D, Albert JT, Eberl DF
  • Publication date:
  • Pagination:
    51, 60
  • Journal:
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Language:
  • Keywords:
    Acoustic Stimulation, Animals, Animals, Genetically Modified, Anion Transport Proteins, Anions, Arthropod Antennae, CHO Cells, Cricetulus, Drosophila Proteins, Drosophila melanogaster, Evoked Potentials, Auditory, Hearing, Mechanotransduction, Cellular, Microscopy, Confocal, Patch-Clamp Techniques, Polymerase Chain Reaction, Sensory Receptor Cells, Transfection, Vocalization, Animal
In mammals, the membrane-based protein Prestin confers unique electromotile properties to cochlear outer hair cells, which contribute to the cochlear amplifier. Like mammals, the ears of insects, such as those of Drosophila melanogaster, mechanically amplify sound stimuli and have also been reported to express Prestin homologs. To determine whether the D. melanogaster Prestin homolog (dpres) is required for auditory amplification, we generated and analyzed dpres mutant flies. We found that dpres is robustly expressed in the fly's antennal ear. However, dpres mutant flies show normal auditory nerve responses, and intact non-linear amplification. Thus we conclude that, in D. melanogaster, auditory amplification is independent of Prestin. This finding resonates with prior phylogenetic analyses, which suggest that the derived motor function of mammalian Prestin replaced, or amended, an ancestral transport function. Indeed, we show that dpres encodes a functional anion transporter. Interestingly, the acquired new motor function in the phylogenetic lineage leading to birds and mammals coincides with loss of the mechanotransducer channel NompC (=TRPN1), which has been shown to be required for auditory amplification in flies. The advent of Prestin (or loss of NompC, respectively) may thus mark an evolutionary transition from a transducer-based to a Prestin-based mechanism of auditory amplification.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
The Ear Institute
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by