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Publication Detail
Karyotyping human chromosomes by optical and X-ray ptychography methods
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Shemilt LA, Verbanis E, Schwenke J, Estandarte AK, Xiong G, Parmar N, Yusuf M, Zhang F, Robinson IK
  • Publication date:
    2014
  • Print ISSN:
    0006-3495
Abstract
Sorting and identifying chromosomes, a process known as karyotyping, is widely used to detect changes in chromosome shapes and gene positions. In a karyotype the chromosomes are identified by their size and therefore this process can be performed by measuring macroscopic structural variables. Chromosomes contain a specific number of base pairs that linearly correlate with their size; therefore it is possible to perform a karyotype on chromosomes using their mass as an identifying factor. Here, we obtain the first images of chromosomes using the novel imaging method of ptychography. We can use the images to measure the mass of chromosomes and perform a partial karyotype from the results. We also obtain high spatial resolution using this technique with synchrotron source X-rays.
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