The design of future hydrogen infrastructure must take into account spatial planning and the geographic positioning of production facilities in relation to demand. A state-of-the-art review of hydrogen supply chain models reveals that there are important trade-offs between centralized production, with more extensive delivery infrastructure, and decentralized production, which has lower distribution costs but higher production costs. This chapter presents the results of a UK scenario case study of hydrogen deployment using a state-of-the-art spatially explicit model, resulting in key insights for prospective hydrogen system planners.