This paper presents a comparative analysis of three areas within London based on measurable attributes of each city block, to assess the degree to which characteristic differences between the neighbourhoods are evident and quantifiable. Both morphological measures of buildings and space syntax measures of streets are used. Results indicate that neighbourhoods are clearly distinguishable, however, the types of measures which best capture that distinction vary depending on the distinction being made. In the cases studied, building morphology alone distinguishes the residential neighbourhoods from mixed use, but the distinction between two residential neighbourhoods requires a combination of building and street measures.