Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of Molecular Immunology
- ICH Infect, Imm, Infla. & Physio Med
- Institute of Child Health
- Faculty of Pop Health Sciences
My research has involved the elucidation of the molecular and cellular defects in inherited immunodeficiency disorders which has resulted in our identification of several disease causing genes. We are now investigating the functions of the protein products of these genes, in both health and disease. We are translating the results of this basic research into new and improved strategies for treatment, principally by the development of techniques for the cure of these disorders by somatic gene therapy techniques.
We have initiated phase I clinical trials for the treatment of X-linked severe combined immunodeficiency (SCID), adenosine deaminase (ADA) deficient SCID, X-linked chronic granulomatous disease (CGD) and Wiskott-Aldrich syndrome using gene therapy techniques.
Student Supervision: I have supervised research students at BSc, MSc, MPhil and PhD level, seeing more than 5 PhD students to completion as Primary supervisor.
|1984||PhD||Doctorat – Immunology||University College London|
|1978||BSc Hons||Bachelor of Science (Honours) – Biochemistry||University of Newcastle upon Tyne|