Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of Neurology
- Clinical & Experimental Epilepsy
- Institute of Neurology
- Faculty of Brain Sciences
I studied Physiological Sciences (undergraduate Medicine) at Oxford University and obtained a DPhil in the laboratory of Julian Jack before resuming my clinical studies at St Thomas' Hospital (London). I then alternated between research in synaptic trasnsmission (including a couple of years with Roger Nicoll, UCSF) and postgraduate medical training in London until I established my own laboratory at the Institute of Neurology in 1992.
My interests span the fundamental mechanisms of synaptic transmission, the computational properties of small neuronal circuits, and alterations in neuronal and circuit excitability in epilepsy and other neurological disorders. The core methods in my lab are in vitro electrophysiology and pharmacology, but we also apply confocal and two-photon laser scanning microscopy, computational simulations, molecular genetic methods, and heterologous expression of mutated ion channels.
I collaborate with Michael Hanna, Henry Houlden, Stephanie Schorge and others to understand the mechanisms of inherited neurological diseases caused by mutations of ion channels (channelopathies).
My laboratory has contributed to the discovery of silent synapses, glutamate spillover, presynaptic GABAA receptors in the cortex, human epilepsy caused by K+ and Ca2+ channel mutations, tonic inhibition in the hippocampus, and Hebbian and anti-Hebbian LTP in hippocampal interneurons.
One of our goals is to understand how phenomena that we have studied at the cellular level (synaptic, extra-synaptic and non-synaptic signalling, different types of long-term potentiation) interact to regulate the excitability of small neuronal circuits. We are also integrating our studies on hippocampal circuit function with knowledge of how interneurons and principal cells fire during different behaviours. This is being approached with a synthesis of experiments and computational simulations.
In collaboration with Matthew Walker, Stephanie Schorge, Rob Wykes and Dennis Kaetzel, my laboratory has developed several promising strategies for gene therapy of focal epilepsy.
I lecture on MSc courses at the Institute of Neurology, and to undergraduates studying Neuroscience at UCL. I also supervise PhD students through the UCL 4-year programme in Neuroscience, as well as students on the Brain Research Trust/MRC-funded programme in clinical neuroscience.
|01-AUG-1997 – 31-JUL-2007||MRC Senior Clinical Fellow||Institute of Neurology||UCL, United Kingdom|
|01-AUG-1992 – 31-JUL-1997||MRC Clinician Scientist Fellow||Clinical Neurology||Institute of Neurology, United Kingdom|
|01-NOV-1990 – 31-JUL-1992||Postdoctoral Research Fellow||Pharmacology||UC San Francisco, United States|
|01-FEB-1990 – 31-OCT-1990||Registrar, Medicine||Medicine||Edgware General Hospital, United Kingdom|
|01-AUG-1989 – 31-JAN-1990||Senior House Officer, Neurology||Neurology||National Hospital for Neurology & Neurosurgery, United Kingdom|
|01-FEB-1989 – 31-JUL-1989||Senior House Officer, Medicine||Medicine||Hammersmith Hospital, United Kingdom|
|01-AUG-1987 – 31-JAN-1989||Nuffield Medical Research Fellow||Physiology||Oxford University, United Kingdom|
|01-OCT-1982 – 30-SEP-1983||Prize Fellow||Magdalen College||Oxford University, United Kingdom|
|2000||FRCP||Fellow of the Royal College of Physicians – Medicine||Royal College of Physicians|
|1990||MRCP||Member of the Royal College of Physicians – Medicine||Royal College of Physicians|
|1986||MBBS||Bachelor of Medicine/Bachelor of Surgery – Medicine||University of London|
|1984||DPhil||Doctor of Philosophy – Physiological Science||University of Oxford|
|1979||BA Hons||Bachelor of Arts (Honours) – Physiological Science||Balliol College, Oxford|