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- Reader in Genomics
- ICH Genetics & Genomic Medicine Prog
- Institute of Child Health
- Faculty of Pop Health Sciences
I have always been interested in applying technological progress to aid biological discovery, and am a firm believer in the value of interdisciplinary collaborations. As a post-doc in the laboratory of Dr David Schatz (Section of Immunobiology, Yale University), we developed the cDNA RDA technique for the detection of differentially expressed genes. After returning to the UK - first to the University of Sussex and then in 1999 to UCL Institute of Child Health - I continued to work on transcriptional responses initially using RDA, and then Affymetrix microarrays. Using microarray expression data and working with the mathematician, Martino Barenco, we developed two mathematical models that predict the transcription factors controlling a dynamic transcriptional response (the DNA damage response).
In 2000, I established the ICH Gene Microarray Centre, which subsequently developed into UCL Genomics (www.genomics.ucl.ac.uk). UCL Genomics is now a collaborative research facility with a small but experienced staff dedicated to developing new approaches and applying the latest research in genomic technologies to a wide range of biological and medical questions. Wherever possible, we work with clinical teams at Great Ormond Street Hospital to translate what we learn into clinical benefit. We have been involved in developing microarray based cancer classification, cfDNA analysis for aneuploidy testing, gene panel sequencing for a range of disease diagnostics, RNA sequencing for rare pathogen discovery and many other applications. Genomics is a rapidly moving field and we aim to keep UCL researchers well placed to benefit from these exciting advances.
My research focuses on the development and application of genomic methods to biological and clinical questions.
Academic Supervision at UCL
Primary Supervisor for five PhD students at UCL: P. Evans (MRC; PhD 2005); D. Brewer, (MRC; PhD 2006), Fredrik Bryntesson: (Human Frontiers; PhD 2002), Ramya Ramanujachar (Children with Leukemia; PhD 2009), Ruth Lyons (Olivia Hodson; PhD 2009).
Secondary Supervisor for 6 PhD students: J. Yeung (PhD 2005), P. Balaraman (2005); E. Balman, Jenner Institute, (2005); M. Woodward (2007); Ching In Lau (current); Lisa Carter (current).
Teaching Activity at UCL
Course Organiser and Lecturer in Applied Genomics; MSc - Cell and Gene Therapy Module (2011 – present)
Course Organiser and Lecturer in Applied Genomics; BSc - Applied Medical Sciences Module (2015 – present)
Course Organiser and Lecturer in Introduction to Applied Genomics in the Clinic; One day CPD course (2015 – present)
Lecturer in Genomics on MRes Biomedicine course (2002 – present).
Lecturer in Genomics on BSc Genetics course (2008 – 2012).
Lecturer in Genomic Technologies on MSc Biomechanical
Engineering course (2007 – 2008)
Lecturer in Transcriptional Analysis on UCL/Birkbeck Gene Microarray Summer School (2002 – 2012).
Lecturer in Transcriptional Analysis on MSc Gene Ontology Module (2010 – present).
|1989||PhD||Doctor of Philosophy – Endocrinology||University College London|
|1985||BA Hons||Bachelor of Arts (Honours) – Natural Sciences||University of Cambridge|