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- Clinical Reader
- ICH - Nephro-Urology Unit
- Dept of Genes, Dev & Disease
- Faculty of Population Health Sciences
Dr Paul Winyard is an Honorary Consultant in Paediatric Nephrology at Great Ormond Street and Head of the Nephro-Urology Research Unit at the Institute of Child Health. After Medical School split between Cambridge (pre-clinical) and Oxford (clinical), he trained in Paediatrics at Charing Cross, Guy's, Oxford, Queen Elizabeth's Hackney and GOS in the UK, with spells at Duke University and Philadelphia in the USA. His first GOS post was in 1990 and he has worked in associated hospitals/universities ever since. He completed his Paediatric Nephrology training in 1999, concurrently finishing a PhD on the Molecular Biology of Renal Malformations.
My research interests follow three major strands:
1. Normal and dysplastic human renal precursor cells. I have generated a panel of normal and abnormal human cell lines from human fetal and postnatal dysplastic kidneys with which to investigate key processes in vitro. These stem-like cells are unique, and no-one else in the world has been able to generate comparable human lines. Capacity to promote normal differentiation in vitro, raises the possibility of using these cells as therapies in vivo. I have established several international collaborations to further exploit these cells.
2. Galectin-3 in cystic kidneys. Polycystic kidney disease (PKD) is common in humans and, despite many trials, there are no firmly established therapies that prevent progression to kidney failure. I demonstrated that lack of galectin-3 promotes cystogenesis (Chiu et al. Am J Path, 2006), suggesting that this lectin may be a natural brake on cyst formation. I am currently investigating galectin-3 therapy in several models of autosomal recessive polycystic kidney disease. Novel therapies arising from this study may be applicable to humans with PKD in future. Intriguingly, pectin, a natural inhibitor of galectin-3 found in many fruits appears protective in experimental renal disease (Kolatsi-Joannou et al, 2011); hence, galectin-3 may have differing effects in the kidney depending on disease and localisation.
3. My clinical research (and practice) centres on children with kidney malformations, particularly those that present before birth. I work with Professor Lyn Chitty (Fetal Medicine and Genetics) and Mr Divyesh Desai (Paediatric Urology) in the Fetal Nephro-Urology clinic at UCLH to investigate kidney/urinary tract malformations. We are collecting amniotic fluid to identify prognostic markers from mid pregnancy. Proteomic analysis has identified several markers that look promising and we hope to collect more samples in the next year to confirm these results. Our aim is to develop prognostic kits for use in routine clinical practice.
I have a long-standing commitment to improving education and teaching of Paediatricians and related specialists, particularly by developing new opportunities for academic careers. I am committed to increasing quality of teaching with increased flexibility and initiated the BSc in Paediatrics which is unique in the UK.
Director iBSc in Paediatrics and Child Health, UCL ICH
Director MSc in Paediatrics and Child Health, UCL ICH
Academic Programme Director, London Speciality School of Paediatrics
Paediatric Academic CSAC, Royal College of Paediatrics and Child Health
Previous major roles
Director of Teaching and Learning at ICH
Programme author and director: Paediatric Academic Clinical Fellows and Lecturers ICH/UCL
Director visiting fellows programme - ICH/GOS
Director student and elective attachments - GOS
Author of education and teaching strategy for first ICH/GOS BRC
Founder of the Otto Wolff lecture series - ICH/GOS
Pioneer automated lecture capture system - ICH
|1988||MRCP||Member of the Royal College of Physicians||Royal College of Physicians|
|1986||BM||Bachelor of Medicine||University of Cambridge|