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Dr Steven Howe
Wolfson Centre for Gene Therapy, Molecular Immunology Unit
Institute of Child Health, 30 Guildford St
London
WC1N 1EH
Tel: +44 (0) 207 9052795
Fax: +44 (0) 207 9052810
Appointment
  • Senior Research Associate
  • ICH - Molecular Immunology Unit
  • Dept of Infection & Immunity
  • Faculty of Population Health Sciences
 
 
Biography
I obtained my BSc (Hons) in Biology from Bristol University, before moving to Imperial College, London to study for my PhD under the supervision of Dr Clare Huxley.  My project was to study the use of artificial chromosomes as tools for gene therapy of diseases such as cystic fibrosis.  

Following my PhD, I joined Professor Adrian Thrasher at the UCL Institute of Child Health to continue working on gene therapy and have been fortunate enough to travel to the University of North Carolina and Harvard for short sabbaticals.  

I am currently at the UCL Institute of Child Health in the Molecular and Cellular Immunology Unit where I now lead a group.
Research Summary

Lentiviral vectors based on HIV make excellent vehicles to deliver genes to both dividing and non-dividing cells.  This makes them useful tools for treating both inherited and acquired diseases, as well as investigating basic biology through gene expression or knockdown.

We are using this technology to study gene transfer and expression in haematopoietic stem cells to try and improve their survival in culture and to enhance stem cell transplantation treatments. Viral vectors are also being used to deliver genes for gene therapy of childhood metabolic disorders, such as Gaucher and Fabry diseases. We are also continually trying to improve the properties of the viral vectors that we use, to improve their stability, simplify their application, reduce their toxicity and enhance their efficacy.  

More details of who we are, and about the work that we do, can be found in the links on this page.  For further information, please get in touch; we are always pleased to discuss our work.

Teaching Summary
I am course director for the MSc in Cell and Gene Therapy (www.ucl.ac.uk/cell-gene-therapy) which offers qualifications at Postgraduate Diploma and Certificate levels as well as a Masters degree, full or part time.

I also deliver lectures on gene therapy at universities and teaching events nationally and internationally, at BSc and MSc levels and organise and speak at public engagement events, such as the British Society of Cell and Gene Therapy.

Several Candidates have obtained their PhD qualification in my group and I am pleased to be currently supervising several more students.
Academic Background
2002 DIC Diploma of the Imperial College Imperial College of Science, Technology and Medicine
2002 PhD Doctor of Philosophy Imperial College of Science, Technology and Medicine
1997 BSc Hons Bachelor of Science (Honours) University of Bristol
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