UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Stephen Hart
Wolfson Centre for Gene Therapy of Childhood Disease, UCL In
30 Guilford Str
London
WC1N 1EH
Tel: 020 7905 2228
Fax: 020 7905 2810
Appointment
  • Professor of Epidemiology and Medical Statistics
  • ICH - Molecular Immunology Unit
  • Dept of Infection & Immunity
  • Faculty of Population Health Sciences
 
 
Research Summary
Gene therapy offers exciting opportunities for the development oftherapies in virtually all areas of medicine. Recent clinical advances arestarting to realise this potential although there remain many challenges amongst which delivery is a key issue. Much of my research has thereforefocused on this challenging area to develop delivery methods compatible withclinical use. In particular I have developed a family of synthetic gene delivery formulations, or nanoparticles, from conceptual stages through to treatment of disease models in vivo.  More recently we have extended our formulations to the delivery of siRNA and other oligonucleotides as well as imaging contrast agents and radiolabels for real-time imaging of delivery in vivo.

 I have established a number of collaborations, exploiting the breadth of high quality research groups at UCL, including Departments of Chemistry, Biochemical Engineering, Centre for Respiratory Medicine, and the Centre for Cardiovascular Biology and Medicine. These collaborations have led to highly productive interdisciplinary hypothesis-driven research, involving synthesis ofnovel reagents, studies to establish the fundamental rules and relationshipsconcerning vector structure and function and correction of animal models ofdisease.

Overall the research areas are non-viral vector development and gene therapy for: 1) gene therapy for cardiovascular diseases (bypass grafts), 2) gene therapy for respiratory diseases (cystic fibrosis), 3) gene therapy for cancer (neuroblastoma), 4) gene therapy for the brain, 5) further vector development.

Teaching Summary

My teaching activity mainly concerns training of research students from MSc to PhD levels.

Academic Background
1991 PhD Doctor of Philosophy University of Cape Town
1986 MSc Master of Science University of the Witwatersrand
1981 BSc Hons Bachelor of Science (Honours) University of Liverpool
Please report any queries concerning the data shown on this page to:

https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by