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Dr Ariberto Fassati
1.3.10
Wohl Virion Centre, UCL
The Cruciform Building, Gower Street
London
WC1E 6BT
Tel: 020 31082138
Appointment
  • Reader in Cellular & Molecular Virology
  • Research Department of Infection
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
 
 
Biography
Ariberto Fassati graduated in Medicine (Summa cum Laude) at the University of Milan, Italy, and specialised in Neurology in 1994. He moved to the UK and obtained a PhD from UMDS Guy's Hospital, London, in 1997 on gene therapy for neuromuscular diseases and was awarded a Wellcome Trust Prize International fellowship to work with Steve Goff at Columbia University, New York. Dr. Fassati returned to the UK in 1999 to work in Robin Weiss's group at UCL, he was awarded a Wellcome Trust Career Development fellowship in 2000 to set up his own group at UCL and a Wellcome Trust University Award in 2004. He is a Reader in Cellular & Molecular Virology (since 2007) and the Director of the Wohl Virion Centre.

Fassati is an Associate Editor of Retrovirology and a faculty member of Faculty1000.
Research Groups
Research Themes
Research Summary
I have three main areas of interest: 1) molecular host-virus interactions; 2) nucleocytoplasmic trafficking of viruses and tRNAs; 3) Transmissible cancers.

As a Wellcome Trust International Fellow I joined Stephen Goff’s lab at Columbia University in 1998 and in 2000 moved to UCL with Robin Weiss. Iinvestigated poorly understood steps of retrovirus infection such as uncoating and intracellular reverse transcription. I discovered that HIV-1 must shed the capsid core early to progress to productive infection, in contrast to oncoretroviruses.

As a Wellcome Trust Career Development Fellow, I worked on nuclear transport of HIV-1, a step essential for infection of relevant target cells. I devised an in vitro system to study host cell components important for viral nuclear transport and, in collaboration with Dirk discovered that the nuclear import receptor importin 7 promotes HIV-1 nuclear import. My lab discovered that importin 7 also promotes nuclear import of DNA in general.

By studying HIV-1 nuclear import my lab discovered that cellular tRNAs are transported back into the nucleus of human cells in an energy dependent way. This new cellular pathway (now called “retrograde tRNA transport”) is conserved from yeast to humans and it is thought to control cell metabolism by modulating tRNA availability in the cytoplasm. We found that HIV-1 evolved to exploit this pathway to enter the nuclei of infected cells.

With Bart Hoogenboom at the UCL Centre for Nanotechnology we are investigating the biophysical properties of the nuclear pore complex (NPC) to better understand nuclear import of viruses and nucleic acids.

With funding from the MRC I have recently set up a high-throughput screening facility in the cat3 lab to investigate host-pathogen interactions by chemical genetics and RNAi. Chemical genetics is an approach whereby small molecules are first screened to find “hits” with the desired phenotype and then the hit molecule is used as a tool to identify the target. We have identified several compounds targeting novel host cell factors important for HIV-1 replication.  Such new "druggable" antiretroviral targets will be further exploited in collaboration with David Selwood (UCL Medicinal Chemistry) and Steve Caddick (UCL Chemistry).

I have contributed to the demonstration that the canine transmissible venereal tumour (CTVT) has a clonal origin and is a cancer transmitted as a cellular parasite. I am collaborating with Michael Stratton and Liz Murchison at the Sanger Institute and Stephan Beck at UCL to understand the genetic and epigenetic mechanisms leading to CTVT regression as a general model for cancer regression.
Teaching Summary
I organize the Molecular Virology course (VIRL3001) at UCL for 3rd year Life Sciences students and MSc students.

The aim of the course is to give the students an up to date insight into molecular virology and viral diseases, with particular focus on new research developments in the field. Five weeks of lectures and tutorials examine the biology of Herpesviruses, Retroviruses including HIV, Hepatitis viruses and Influenza viruses. New viruses and transmission of viruses from animals to humans are also explored. Moreover, lectures provide insight on how certain viruses cause cancer in humans and animals and on the molecular interactions between viruses and their hosts. Two lectures are dedicated to anti-viral drugs and viral gene therapy. The last lectures cover the breath of immune responses to viral infections.

I also contribute lectures to the IMM2002 course and to the MSc in Infection.
Academic Background
1997 PhD Doctor of Philosophy United Medical and Dental Schools of Guy's and St.. Thomas's Hospitals
1994 SPL Specialist Universita degli Studi di Milano
1991 MD Doctor of Medicine Universita degli Studi di Milano
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