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Dr Clare Bennett
Dept of Haematology, UCL Hampstead Campus
Rowland Hill street
London
NW3 2PF
Appointment
  • Senior Lecturer
  • Research Department of Haematology
  • Cancer Institute
  • Faculty of Medical Sciences
 
 
Research Groups
Research Themes
Research Summary
The high numbers of accessible DC in the skin compared to other vaccination sites has made the skin an attractive target for vaccination protocols, and cutaneous vaccination has been shown to elicit potent systemic cellular immune responses in pre-clinical immunisation models. However, it is not known which skin DC are required to prime functional protective T cells following cutaneous immunisation. One of the aims of our lab is to use cutaneous vaccination with lentiviral vectors to investigate the requirement for different DC in the generation of post-vaccination immunity. The goal of our work is to address the feasibility of targeting skin DC via cutaneous lentiviral vaccination to prime functional anti-leukaemia T cell responses in vivo. This research, with that of our collaborators, will lead to the design of superior vaccination strategies for leukaemia immunotherapy.
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