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Dr Emmanuel Boucrot
Room 102
Department of Structural and Molecular Biology
Darwin Building , Gower Street
London
WC1E 6BT
Tel: Extn 34302
Appointment
  • Reader in Molecular Cell Biology
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography

2017               Fellow of the Royal Society of Biology (FRSB) 

2016               Reader (Associate Professor) in Molecular Cell Biology 

2015               Fellow of the Higher Education Academy (FHEA)

2014               Lister Institute Research Prize 

2011 - 2016    BBSRC David Phillips Research Fellow, University College London, London (UK)

2008 - 2011    MRC Career Development Fellow, MRC Laboratory of Molecular Biology, Cambridge (UK)
2006 - 2008    HFSP Postdoctoral Fellow, Harvard Medical School, Boston (US) 

2005 - 2006    EMBO Postdoctoral Fellow, Harvard Medical School, Boston (US) 
2001 - 2005    PhD in Immunology, University of Aix-Marseille II, Marseille (France) 


Publications: 27 research papers, 6 review articles. h-index 23, over 5,000 citations


Selected research papers: 

- Renard HF et al. (2015) 'Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis' Nature  517 (7535) pp.493-6

- Boucrot E$ et al. (2015) 'Endophilin marks and controls a clathrin-independent endocytic pathway' Nature  517 (7535) pp.460-5

- Boucrot E* et al.  (2012) 'Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains' Cell 149 (1) pp.124-36

- Henne WM*, Boucrot E*,$ et al. (2010) 'FCHo proteins are nucleators of clathrin-mediated endocytosis'  Science  328 (5983) pp.1281-4    

- Boucrot E et al. (2005) 'The intracellular fate of Salmonella depends on the recruitment of kinesin'  Science 308 (5725) pp.1174-8

  

* joint first authors    $ corresponding author

Full list of publications

Research Summary

Understanding molecular mechanisms and establishing functions of intracellular membrane trafficking in health and disease. 


Project 1: Mechanisms of fast endophilin-mediated endocytosis (FEME)

Endocytosis is the process by which cells acquire substances from the extracellular space and  internalise transmembrane cell surface proteins, of which receptors are a major class. The process occurs through invaginations of the plasma membrane forming endocytic vesicles that, once pinched off the surface, are transported to endosomes and, from there, sorted to the appropriated cellular destinations depending on the fate of the receptor. We recently identified a new pathway of endocytosis, the Fast Endophilin-Mediated Endocytosis (FEME) pathway (Boucrot et al. 2015 Nature; Renard et al. 2015 Nature). Our goal is to establish the functions and molecular mechanisms of this novel route of entry into cells.


This project is funded by a 2014 Lister Institute Research Prize



Current group members:

Ms Claudia Hinze (PhD student funded by the British Heart Foundation)

Ms Alessandra Casamento (PhD student funded by BBSRC)

Mr Shaan Subramanian (PhD student funded by MRC)


Alumni: Dr Antonio PA Ferreira (PhD student 2011-2016, now PDRA at Harvard University, US), Dr Kieran McGourty (PDRA, 2012-2016, now Lecturer at U. of Limerick, IRL), Dr Ana Mendes Pereira (PDRA, 2012-2016, now Senior Scientific Officer at King's College London, UK), 


Teaching Summary

BIOC2003 - Lecturer and Course Organiser

BCBC006S6 (Birkbeck) Advanced Cell Biology - Lecturer and joint Module Organiser

BIOC1007, BIOC2001 and BIOC3301 - Tutor

BIOC3027 - Supervisor

BIOCM101 - Supervisor

UCL PhD in Molecular Cell Biology - Tutor

UCL PhD, MRes and MSc - Supervisor


Academic Background
1998 BSc Bachelor of Science – Biochemistry Universite de Genève
  FHEA ATQ03 - Recognised by the HEA as a Fellow  
2005 PhD Doctor of Philosophy – Immunology Universite de la Mediterranée (Aix Marseille II)
2001 MRes Master of Research – Immunology Universite de la Mediterranée (Aix Marseille II)
2000 MSc Master of Science – Biochemistry Universite de Genève
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