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- Senior Lecturer
- Div of Medicine
- Faculty of Medical Sciences
The research programme of the Wolfson Drug Discovery Unit, directed by Professor Sir Mark Pepys FRS, is highly collaborative and focused on development of effective therapies for treatment of amyloidosis and other major diseases associated with local amyloid deposition, and cardiovascular disease.
My current research efforts are focused principally on: (1) Thermodynamic characterisation of complexes formed between novel compounds and C-reactive protein (CRP), serum amyloid P component (SAP) or transthyretin (TTR), by isothermal titration and differential scanning calorimetry; (2) Characterisation of cellular mechanisms responsible for removal of amyloid in tissues of mice that receive novel treatment regimes; (3) Evaluation of ex vivo amyloid fibrils, and amyloid-like fibrils produced in vitro, for binding by anti-fibril antibodies and/or SAP, and other studies of amyloid fibril structure; (4) Evaluation of binding by novel compounds to amyloid deposits in situ in tissues of patients with systemic and hereditary amyloidoses.
|1995||PhD||Doctor of Philosophy||University of London|