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- Professor of Molecular Cell Biology
- Inst for Liver and Digestive Hlth
- Div of Medicine
- Faculty of Medical Sciences
The Institute for Liver and Digestive Health comprises research spanning basic, translational and clinical science. Our focus is on tissue fibrosis, which occurs in a wide range of diseases but for which there is currently no effective treatment. Fibrosis is caused by an aberrant increase in components of the extracellular matrix that typically becomes resistant to normal breakdown mechanisms. This can occur in many different tissues, such as liver, lung and skin as a result of a wide range of causes, including diet, noxious airborne agents, infection and genetics.
Our research employs a range of molecular, cellular and tissue-based approaches with collaborators in academia and industry. Amongst these, we have exploited the unique ability of proteomics to non-prescriptively identify the wide range of proteins found within fibrotic matrices. This work is complemented by laser capture micro-dissection of matrices and pro-fibrotic cell populations, mRNA profiling and immunohistochemical validation.
Undergraduate teaching at UCL includes: personal tutor (Medicine); academic tutor (Applied Medical Sciences); lecturer (iBSc Clinical Sciences & Applied Medical Sciences); and core module lead (Applied Medical Sciences). Postgraduate teaching includes MSc laboratory project supervisor (Drug Design), and PhD student primary and secondary supervisor.
|1986||PhD||Doctor of Philosophy – Biochemistry||University of Bristol|