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Dr Jill Norman
Centre for Nephrology, 2nd Floor
University College Medical School, Royal Free Campus
London
NW3 2PF
Tel: 0044 20 7794 0500
Fax: 0044 20 7317 8591
Appointment
  • Reader in Nephrology
  • Internal Medicine
  • Div of Medicine
  • Faculty of Medical Sciences
 
 
Research Groups
Research Themes
Research Summary
The aim of this work is to investigate the cellular and molecular mechanisms underlying the pathogenesis of progressive fibrosis of the kidney, which is the cardinal feature of chronic kidney disease (CKD). Although many progressive diseases are glomerular in origin, it is tubulointerstitial involvement that best predicts progression. In understanding how glomerular injury is transmitted to the tubulointerstitium, our group has suggested an important role for hypoxia; an idea formalised as the Chronic Hypoxia Hypothesis (Fine et al Kidney Int, 53 Suppl 65:S74-S78, 1998). In support of this hypothesis, in vivo, in a model of progressive renal disease, tissue hypoxia precedes renal scarring and in vitro studies have demonstrated that hypoxia (1% O2) can promote a fibrogenic phenotype in tubular epithelial cells and renal fibroblasts. Current studies are centred on understanding of the role of hypoxia in the pathogenesis of renal fibrosis. Specific areas of investigation include the mechanisms of hypoxic regulation of expression of fibrogenic genes; the control of fibroblast to myofibroblast differentiation; and the role of fibroblast-endothelial cell and fibroblast-epithelial cell interactions in the pathogenesis of fibrosis.
Academic Background
1981 PhD Doctor of Philosophy University of London
1977 BSc Hons Bachelor of Science (Honours) University College London
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