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Dr Laura Horsfall
Upper Third Floor
Royal Free Hospital
Rowland Hill Street
London
Appointment
  • Research Associate
  • Primary Care & Population Health
  • Institute of Epidemiology & Health
  • Faculty of Population Health Sciences
 
 
Biography
My academic background is in Genetics (BSc), Health Services Research (MSc) and Molecular Epidemiology (PhD). I have also spent a number of years working in the science industry as a molecular biologist, biotechnology industry analyst and most recently as a consultant for a company providing health economics/patient reported outcomes services to the pharmaceutical industry. I am interested in the role of biomarkers (serum molecules and genes) for predicting disease risk and drug response in the primary care setting. Since joining UCL as a full time researcher in 2009, I have worked with longitudinal datasets to examine the role of serum antioxidants and related genetic variation in cardiovascular and respiratory disease. 
Research Themes
Research Summary

My current research focuses on the role of purported “antioxidant” molecules including bilirubin, urate and dietary derived compounds for predicting disease and as potential therapeutic targets. Since joining UCL in 2009, I have been using large longitudinal datasets from primary care health records to investigate non-linear relationships and interactions between serum antioxidants, environmental exposures and complex disease risk. Molecules of particular interest are those with a heritable component and where causal relationships can be supported using genotypes as instrumental variables (“Mendelian randomization”). I have published on a range on conditions including cardiovascular, neurological and cancer although my main interest is smoking-related respiratory disease.

Teaching Summary
I develop materials for and teach on the Primary Care Research Database training courses held at UCL PCPH.
Academic Background
2011 PhD Doctor of Philosophy University College London
2005 MSc Master of Science University of York
2000 BSc Bachelor of Science University College London
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