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Dr Sean Davidson
3rd floor
The Hatter Cardiovascular Inst
67 Chenies Mews
  • Senior Research Fellow
  • Hatter Cardiovascular Institute
  • Institute of Cardiovascular Science
  • Faculty of Pop Health Sciences
Research Summary

I am a senior research associate at the Hatter Cardiovascular Inst, investigating cardiac injury during ischaemia and reperfusion. The aim is eventually to find new ways of preserving the heart from injury during a heart attack.

Two of my main topics of interest are exosomes and SDF-1. Exosomes are nano-sized vesicles which can communicate between cells, carrying proteins and miRNA. We have shown that exosomes in the blood are cardioprotective and are studying the mechanism, and their role. We are learning how to harness the power of exosomes to the benefit of patients. SDF-1 is a chemo-attractant cytokine - or a "chemokine" - which can attract stem cells to the heart, and can also directly activate signaling pathways in the heart. We are developing novel reagents to detect SDF-1, understand its role in the heart, and to deliver it to the heart therapeutically.

One of my favourite techniques is to use powerful imaging techniques such as confocal and multiphoton microscopy to visualize real-time, physiological changes in cardiac cells and hearts. Using fluorescent dyes it is possible to detect changes in such important parameters as oxidative stress, Calcium, and mitochondrial activity.

Academic Background
1998 PhD Doctor of Philosophy – Biochemistry To be updated
1991 BSc Hons Bachelor of Science (Honours) – Biochemistry University of Melbourne
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