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Prof Shin-Ichi Ohnuma
Institute of Ophthalmology, UCL
11-43 Bath Street
London
EC1V 9EL
Appointment
  • Professor
  • Inst Ophthalmology - Ocular Biology
  • Institute of Ophthalmology
  • Faculty of Brain Sciences
 
 
Research Groups
Research Themes
Research Summary
Embryonic retina is formed through a combination of multiple developmental processes including neural induction, eye field specification, eye cup formation, cell fate determination, lamination, and differentiation. Our aim is to understand the detailed molecular mechanism of whole retinogenesis. In particular, our main focus of research is on the mechanism of co-ordination of cell cycle regulation with developmental processes. Although the cell cycle needs to be co-ordinated with many aspects of developmental processes, and the defects of the co-ordination are the causes of many human diseases - such as cancer and some retinal disorders - little is known about the mechanism. To determine the mechanism, we use the amphibian retina as a model system. This system is ideal for detailed and fast functional analysis of retinogenesis. Through a combination of in vivo and in vitro approaches, our group is actively searching novel genes
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